FB2026_02 , released June 18, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Trf2, Iswi
FlyBase ID
FBig0000096872
Interaction Network
Interactions Browser links
Trf2 network
Iswi network
Reported Interactions
FBrf0155489-1.coIP.WB
Reference
Hochheimer et al., 2002
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage 2embryonic stage 15blastoderm stagegastrula stageembryonic stage 8embryonic stage 9embryonic stage 6early extended germ band stageextended germ band stageembryonic stage 4embryonic cycle 9late extended germ band stageembryonic stage 5embryonic stage 12embryonic stage 11embryonic stage 3embryonic stage 13embryonic stage 14embryonic stage 10embryonic stage 7
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Trf2 

TRF2

bait
Iswi 

ISWI

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was embryonic nuclear extract; bait produced from endogenous gene; prey produced from endogenous gene.

(Hochheimer et al., 2002)
FBrf0192356-1.CH.WB
Reference
Kopytova et al., 2006
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Trf2 

p175

bait
Iswi 

ISWI

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Nuclear extract from Drosophila embryo was first fractionated on a Superose 6 column, and peak Trf2 fractions were further fractionated on a heparin column.

(Kopytova et al., 2006)

Trf2 and Iswi co-fractionate together as part of a ~1MDa complex.

(Kopytova et al., 2006)
FBrf0192356-2.coIP.WB
Reference
Kopytova et al., 2006
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Trf2 

p175

bait
Iswi 

ISWI

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)