FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Kdm5, Myc
FlyBase ID
FBig0000098378
Interaction Network
Interactions Browser links
Kdm5 network
Myc network
Reported Interactions
FBrf0193047-1.coIP.WB
Reference
Secombe et al., 2007
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
Kdm5 

Lid

bait
Myc 

dMyc

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from endogenous gene; prey produced from endogenous gene.

(Secombe et al., 2007)
FBrf0193047-3.coIP.WB
Reference
Secombe et al., 2007
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
Myc 

dMyc

bait
Kdm5 

Lid

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from endogenous gene; prey produced from endogenous gene.

(Secombe et al., 2007)
FBrf0193047-6.PD.A
Reference
Secombe et al., 2007
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Myc 

dMyc

bait

GST tag

Myc 
Kdm5 

Lid

prey

[35]S label

Kdm5 
Kdm5 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Myc 
C-terminal bHLHZ region
sufficient binding region
aa 508-717
Kdm5 
JmjC domain
sufficient binding region
aa 499-740
Kdm5 
C5HC2 zinc finger domain
sufficient binding region
aa 797-1092
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey produced and labeled by in vitro translation.

(Secombe et al., 2007)

lid binds dm (dMyc) but not Max.

(Secombe et al., 2007)

Two regions of lid bind independently to dm (dMyc).

(Secombe et al., 2007)
FBrf0212448-1.PD.A
Reference
Li et al., 2010
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Myc 

Myc

bait

GST tag

Myc 
Kdm5 

lid

prey

[35]S label

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Myc 
interaction domain
sufficient binding region
aa 508-717
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey produced and labeled by in vitro translation.

(Li et al., 2010)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)