FB2025_05 , released December 11, 2025
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Egfr, Abl
FlyBase ID
FBig0000099509
Interaction Network
Interactions Browser links
Egfr network
Abl network
Reported Interactions
FBrf0222949-25.Y2H
Reference
Bianco et al., 2007
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Egfr 

EGFR

bait
Egfr 
Egfr 
Abl 

Abl

prey
Abl 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Egfr 
intracellular domain
sufficient binding region
Egfr 
intracellular domain
mutation decreasing interaction
aa 1095-1342

all Tyr residues mutated to Phe in this region

Abl 
SH3-SH2 domains
sufficient binding region
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Two-hybrid system: yeast

(Bianco et al., 2007)

Source was yeast cell line; bait produced as transgenic fusion protein; prey produced as transgenic fusion protein (prey was previously cloned reagent).

(Bianco et al., 2007)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)