FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
SmD1, r2d2
FlyBase ID
FBig0000100571
Interaction Network
Interactions Browser links
SmD1 network
r2d2 network
Reported Interactions
FBrf0222990-2.coIP.WB
Reference
Xiong et al., 2013
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
SmD1 

SmD1

bait

FLAG tag

r2d2 

R2D2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Xiong et al., 2013)

Dcr-2 and r2d2 each interact with SmD1. Functional studies confirm that SmD1 is required for RNAi and antiviral immunity.

(Xiong et al., 2013)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)