FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
drl, Drl-2
FlyBase ID
FBig0000100875
Interaction Network
Interactions Browser links
drl network
Drl-2 network
Reported Interactions
FBrf0222811-2.coIP.WB
Reference
Petrova et al., 2013
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
drl 

DRL

bait

FLAG tag

Drl-2 

DRL-2

prey

HA tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Petrova et al., 2013)

drl heterodimerizes with Drl-2.

(Petrova et al., 2013)
FBrf0228474-3.coIP.WB
Reference
Reynaud et al., 2015
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
drl 

DRL

bait

Fc tag

drl 
Drl-2 

DRL-2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
drl 
extracellular domain
sufficient binding region
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in baculovirus-infected Sf9 insect cell system; prey derived from transfected S2 cell extract.

(Reynaud et al., 2015)

The drl-Drl-2 interaction is observed only in the presence of Wnt5.

(Reynaud et al., 2015)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)