FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
SmD1, Dcr-2
FlyBase ID
FBig0000101106
Interaction Network
Interactions Browser links
SmD1 network
Dcr-2 network
Reported Interactions
FBrf0222990-1.coIP.WB
Reference
Xiong et al., 2013
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
SmD1 

SmD1

bait

FLAG tag

Dcr-2 

Dcr-2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Xiong et al., 2013)

Dcr-2 and r2d2 each interact with SmD1. Functional studies confirm that SmD1 is required for RNAi and antiviral immunity.

(Xiong et al., 2013)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)