FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
Open Close
General Information
Interaction Type
physical association
Interacting Genes
dpp, gbb
FlyBase ID
FBig0000102713
Interaction Network
Interactions Browser links
dpp network
gbb network
Reported Interactions
FBrf0187482-1.coIP.WB
Reference
Serpe et al., 2005
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
dpp 

Dpp

bait

HA tag

gbb 

Gbb

prey

FLAG tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Serpe et al., 2005)
FBrf0187482-2.coIP.WB
Reference
Serpe et al., 2005
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
gbb 

Gbb

bait

FLAG tag

dpp 

Dpp

prey

HA tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Serpe et al., 2005)
FBrf0224412-1.coIP.WB
Reference
Tian and Jiang, 2014
Description
physical association
Assay
Collection
Source/Stage
adult midgut / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
gbb 

Gbb

bait

GFP tag

dpp 

Dpp

prey

HA tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was adult midgut of transgenic fly line; bait produced from tagged transgenic construct; prey produced from tagged transgenic construct.

(Tian and Jiang, 2014)
FBrf0237250-4.CM.WB
Reference
Anderson and Wharton, 2017
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
gbb 

gbb

neutral component

HA tag

gbb 

gbb

neutral component

HA tag

gbb 
gbb 

gbb

neutral component

HA tag

gbb 
dpp 

dpp

neutral component

HA tag

dpp 

dpp

neutral component

HA tag

dpp 

dpp

neutral component

HA tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
gbb 
C-terminal ligand domain
sufficient binding region
aa 326-455
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was conditioned media from S2 cell line; proteins produced from transfected constructs.

(Anderson and Wharton, 2017)

Dimers detected among several different gbb cleavage products: ProGbb, Gbb38, Gbb15 homodimers and ProGbb-Gbb15 and Gbb38-Gbb15 hemidimers.

(Anderson and Wharton, 2017)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (3)