FB2026_02 , released June 18, 2026
Physical Interaction report
Open Close
General Information
Interaction Type
physical association
Interacting Genes
TM9SF2, PGRP-LC
FlyBase ID
FBig0000103294
Interaction Network
Interactions Browser links
TM9SF2 network
PGRP-LC network
Reported Interactions
FBrf0227121-1.coIP.WB
Reference
Perrin et al., 2015
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
TM9SF2 

TM9SF2

bait

GFP tag

PGRP-LC 

PGRP-LC

prey

V5 tag

PGRP-LC 
PGRP-LC 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
PGRP-LC 
interaction domain
sufficient binding region
aa 145-500

coordinates relative to PGRP-LC-PA (LCx)

PGRP-LC 
cytoplasmic domain
necessary binding region
aa 145-263

coordinates relative to PGRP-LC-PA (LCx)

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Perrin et al., 2015)

Deletion of the entire PGRP-LC cytoplasmic domain disrupts the interaction with TM9SF2 and TM9SF4.

(Perrin et al., 2015)
FBrf0227121-3.coIP.WB
Reference
Perrin et al., 2015
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
PGRP-LC 

PGRP-LC

bait

V5 tag

TM9SF2 

TM9SF2

prey

GFP tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Perrin et al., 2015)
FBrf0227121-5.coIP.WB
Reference
Perrin et al., 2015
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
TM9SF2 

TM9SF2

bait

GFP tag

PGRP-LC 

PGRP-LC

prey

FLAG tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was flies of transgenic fly line; bait produced from tagged transgenic construct; prey produced from tagged transgenic construct.

(Perrin et al., 2015)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)