FB2026_02 , released June 18, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
KCNQ, ScsβA
FlyBase ID
FBig0000103489
Interaction Network
Interactions Browser links
KCNQ network
ScsβA network
Reported Interactions
FBrf0205141-1.Y2H
Reference
Gao et al., 2008
Description
physical association
Assay
Collection
Source/Stage
organism / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
KCNQ 

dKCNQ

bait

fused to GAL4 DNA-binding domain

KCNQ 
ScsβA 

CG11963

prey

fused to GAL4 activation domain

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
KCNQ 
C-terminal tail
sufficient binding region
aa 266-808

coordinates relative to KCNQ-PE

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was yeast cell line; bait produced as transgenic fusion protein; prey produced as transgenic fusion protein (prey from adult cDNA expression library).

(Gao et al., 2008)

Two-hybrid system: yeast GAL4-BD/GAL4-AD

(Gao et al., 2008)
FBrf0205141-2.coIP.WB
Reference
Gao et al., 2008
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
KCNQ 

dKCNQ

bait

FLAG tag

ScsβA 

CG11963

prey

MYC tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Both KCNQ and skap are integral membrane proteins, as determined by biotinylation assay.

(Gao et al., 2008)

Source was cell extract of tsA-201 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Gao et al., 2008)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)