FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Abi, Ptp61F
FlyBase ID
FBig0000103793
Interaction Network
Interactions Browser links
Abi network
Ptp61F network
Reported Interactions
FBrf0201419-1.PD.WB
Reference
Huang et al., 2007
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
Abi 

Abi

bait

GST tag

Abi 
Abi 
Ptp61F 

PTP61F

prey
Ptp61F 
Ptp61F 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Ptp61F 
active site residue 203
mutation increasing interaction
aa 203

D203A, substrate trapping mutant

Ptp61F 
proline-rich motif 1
mutation disrupting interaction
PPPLPP

PPPLPP mutated to PAALAP

Abi 
SH3 domain
sufficient binding region
Abi 
SH3 domain
necessary binding region
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Huang et al., 2007)

Knockdown of Ptp61F increases phosphorylated Abi levels.

(Huang et al., 2007)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)