FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
polo, cnn
FlyBase ID
FBig0000103921
Interaction Network
Interactions Browser links
polo network
cnn network
Reported Interactions
FBrf0229797-1.coIP.WB
Reference
Eisman et al., 2015
Description
physical association
Assay
Collection
Source/Stage
/ embryonic stage 1embryonic stage 4embryonic stage 3embryonic cycle 6embryonic cycle 5embryonic cycle 8embryonic cycle 7embryonic cycle 3embryonic cycle 4embryonic cycle 9embryonic stage 2
Cell line used
Participants
Corresponds to
Reported as
Role
Note
polo 

Cnn

bait
cnn 

Polo

prey
cnn 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
cnn 
necessary residues
necessary binding region
aa 22, 27
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was embryos of transgenic fly line; bait produced from endogenous gene; prey produced from endogenous gene.

(Eisman et al., 2015)
FBrf0232573-1.coIP.WB
Reference
Eisman et al., 2016
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
polo 

polo

bait
cnn 

cnn

prey

GFP tag

cnn 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
cnn 
exon1A polo-interacting motif
mutation disrupting interaction
aa 22-27

S22A, T27A, coordinates relative to cnn-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

GFP-tagged cnn was expressed in cnn null mutant embryos.

(Eisman et al., 2016)

Source was embryos of transgenic fly line; bait produced from endogenous gene; prey produced from tagged transgenic construct.

(Eisman et al., 2016)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)