FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
msl-3, Top2
FlyBase ID
FBig0000104997
Interaction Network
Interactions Browser links
msl-3 network
Top2 network
Reported Interactions
FBrf0225790-3.coIP.WB
Reference
Cugusi et al., 2013
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
msl-3 

MSL3

bait

FLAG tag

Top2 

Topo II

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Cugusi et al., 2013)

The interaction of Top2 with msl-3 is RNA-dependent (disrupted by RNase treatment).

(Cugusi et al., 2013)

The interaction of Top2 with tagged msl-3 is more efficient when other components of the MSL complex are co-transfected (overexpressed).

(Cugusi et al., 2013)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)