FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Mef2, Tbp
FlyBase ID
FBig0000105410
Interaction Network
Interactions Browser links
Mef2 network
Tbp network
Reported Interactions
FBrf0222977-1.coIP.WB
Reference
Clark et al., 2013
Description
physical association
Assay
Collection
Source/Stage
organism / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Mef2 

MEF2

bait
Tbp 

TBP

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was adults of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

(Clark et al., 2013)
FBrf0222977-2.coIP.WB
Reference
Clark et al., 2013
Description
physical association
Assay
Collection
Source/Stage
embryonic/larval fat body / third instar larval stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Mef2 

MEF2

bait

HA tag

Mef2 
Tbp 

TBP

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Mef2 
p70 S6K phosphorylation site Thr20
mutation disrupting interaction
aa 20

T20E, coordinates relative to Mef2-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was larval fat bodies of transgenic fly line; bait produced from tagged transgenic construct; prey produced from endogenous gene.

(Clark et al., 2013)

Mutations that mimic the T20 phosphorylated state disrupt the Mef2-Tbp interaction.

(Clark et al., 2013)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)