FB2026_02 , released June 18, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Cbl, Egfr
FlyBase ID
FBig0000106215
Interaction Network
Interactions Browser links
Cbl network
Egfr network
Reported Interactions
FBrf0093160-1.PD.WB
Reference
Meisner et al., 1997
Description
physical association
Assay
Collection
Source/Stage
organism / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Cbl 

DCbl

bait

GST tag

Egfr 

EGF receptor

prey

fused to torso extracellular domain

Egfr 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Egfr 
intracellular domain
sufficient binding region
aa 844-1377

coordinates relative to Egfr-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey derived from transgenic embryonic extract.

(Meisner et al., 1997)
FBrf0093510-1.coIP.WB
Reference
Hime et al., 1997
Description
physical association
Assay
Collection
Source/Stage
organism / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Cbl 

D-Cbl

bait
Egfr 

DER

prey
Egfr 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Egfr 
intracellular region
sufficient binding region
aa 844-1377

coordinates relative to Egfr-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was adults of transgenic fly line; bait produced from tagged transgenic construct; prey produced from endogenous gene.

(Hime et al., 1997)
FBrf0237228-7.PD.WB
Reference
Kim et al., 2017
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2R+
Participants
Corresponds to
Reported as
Role
Note
Cbl 

D-Cbl

bait

GST tag

Egfr 

EGFR

prey

FLAG tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey derived from transfected S2R+ cells.

(Kim et al., 2017)

Treatment of cells with spi increases the Cbl-Egfr interaction. Adding increasing amounts of a synthetic phosphopeptide encompassing Tyr1271 (aa 1263-1282) or the Y1271F Egfr mutation decreases the spi induced Cbl-Egfr interaction.

(Kim et al., 2017)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (3)