FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
DIP-η, dpr4
FlyBase ID
FBig0000107731
Interaction Network
Interactions Browser links
DIP-η network
dpr4 network
Reported Interactions
FBrf0230454-18.ELISA
Reference
Carrillo et al., 2015
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
dpr4 

dpr4

bait

Fc tag

DIP-η 

DIP-η

prey

alkaline phosphatase tag, COMP pentamerization motif

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait derived from conditioned media of transfected S2 cell line; prey derived from conditioned media of transfected S2 cell line.

(Carrillo et al., 2015)
FBrf0230454-75.ELISA
Reference
Carrillo et al., 2015
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
DIP-η 

DIP-η

bait

Fc tag

dpr4 

dpr4

prey

alkaline phosphatase tag, COMP pentamerization motif

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait derived from conditioned media of transfected S2 cell line; prey derived from conditioned media of transfected S2 cell line.

(Carrillo et al., 2015)
FBrf0241075-44.SPR
Reference
Cosmanescu et al., 2018
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
DIP-η 

DIP-η

bait
DIP-η 
dpr4 

Dpr4

prey
dpr4 
dpr4 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
DIP-η 
extracellular domain
sufficient binding region
aa 31-338

coordinates relative to DIP-η-PB

dpr4 
extracellular domain
sufficient binding region
aa 32-245
dpr4 
extracellular domain residues 82,136
mutation disrupting interaction
aa 82,136

K82H,K136V

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in HEK293F cells; prey produced as a recombinant fusion protein in HEK293F cells.

(Cosmanescu et al., 2018)

Kd = 77.7uM

(Cosmanescu et al., 2018)
FBrf0241075-60.XC
Reference
Cosmanescu et al., 2018
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
DIP-η 

DIP-η

neutral component
DIP-η 

DIP-η

neutral component
DIP-η 
DIP-η 

DIP-η

neutral component
DIP-η 
dpr4 
dpr4 

Dpr4

prey
dpr4 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
DIP-η 
extracellular domain
sufficient binding region
aa 31-338

coordinates relative to DIP-η-PB

dpr4 
extracellular domain
sufficient binding region
aa 32-245
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; proteins produced as a recombinant fusion proteins in HEK293F cells.

(Cosmanescu et al., 2018)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)