FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
Interacting Genes
FlyBase ID
FBig0000108803
Interaction Network
Interactions Browser links
nwk network
Cdc42 network
Reported Interactions
FBrf0205746-10.ENZ
Description
physical association
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
nwk 

Nwk

ancillary

His tag

nwk 

Nwk

ancillary

His tag

nwk 
nwk 

Nwk

ancillary

His tag

nwk 

Cdc42

ancillary

His tag

Cdc42

ancillary

His tag

Cdc42

ancillary

His tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
nwk 
N-terminal region
sufficient binding region
aa 1-754

coordinates relative to nwk-PB

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; proteins produced as a recombinant fusion protein in bacterial system.

Bovine Arp2/3 complex was mixed with pyrene labeled actin, to which WASp, nwk and Cdc42 were added in various combinations. Actin polymerization was monitored by fluorescence.

External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)