FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
InR, Ilp5
FlyBase ID
FBig0000108920
Interaction Network
Interactions Browser links
InR network
Ilp5 network
Reported Interactions
FBrf0212648-3.CB
Reference
Sajid et al., 2011
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
InR 

InR

bait
Ilp5 

Ilp5

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in S2 cell culture; bait produced from endogenous gene; prey produced in a yeast expression system.

(Sajid et al., 2011)

BD isoform of Ilp5 binds InR with higher affinity than C4 isoform.

(Sajid et al., 2011)
FBrf0257771-1.EM
Reference
Viola et al., 2023
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
InR 

InR

neutral component
InR 

InR

neutral component
InR 
InR 

InR

neutral component
InR 
Ilp5 

DILP5

neutral component
Ilp5 

DILP5

neutral component
Ilp5 

DILP5

neutral component
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
InR 
ectodomain
sufficient binding region
aa 264-1309
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; InR protein produced as a recombinant fusion protein in baculovirus and insect cell system; Ilp5 was gifted from Novo Nordisk.

(Viola et al., 2023)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)