FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Diap2, imd
FlyBase ID
FBig0000108994
Interaction Network
Interactions Browser links
Diap2 network
imd network
Reported Interactions
FBrf0209837-1.coIP.WB
Reference
Paquette et al., 2010
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2[star]
Participants
Corresponds to
Reported as
Role
Note
Diap2 

DIAP2

bait
imd 

IMD

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Diap2 interacts preferentially with the imd cleavage product.

(Paquette et al., 2010)

Source was cell extract of S2[star] cell line; bait produced from endogenous gene; prey produced from endogenous gene.

(Paquette et al., 2010)
FBrf0209837-2.PD.WB
Reference
Paquette et al., 2010
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
Diap2 

DIAP2

bait

GST tag

Diap2 
Diap2 
Diap2 
imd 

IMD

prey

HA or V5 tag

imd 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
imd 
interaction domain residue 31
mutation decreasing interaction
aa 31

A31V

Diap2 
N-terminal domain
sufficient binding region
unspecified

RING domain deleted

Diap2 
N-terminal domain residue 149
mutation decreasing interaction
aa 149

C149G

Diap2 
N-terminal domain
mutation disrupting interaction
aa 149,249

C149G,C249G

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Paquette et al., 2010)
FBrf0218688-7.coIP.WB
Reference
Meinander et al., 2012
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
imd 

imd

bait

V5 tag

Diap2 

Diap2

prey

GST tag

Diap2 
Diap2 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Diap2 
BIR domains
sufficient binding region
aa 1-338
Diap2 
BIR domain residues 149,249
mutation disrupting interaction
aa 149,249

C149G,C249G

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Meinander et al., 2012)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)