FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
wrapper, Nrx-IV
FlyBase ID
FBig0000109836
Interaction Network
Interactions Browser links
wrapper network
Nrx-IV network
Reported Interactions
FBrf0207445-1.coIP.WB
Reference
Wheeler et al., 2009
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
wrapper 

Wrapper

bait
Nrx-IV 

Nrx-IV

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was embryos of transgenic fly line; bait produced from tagged transgenic construct; prey produced from endogenous gene.

(Wheeler et al., 2009)
FBrf0207445-2.BA.FM
Reference
Wheeler et al., 2009
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
wrapper 

Wrapper

neutral component
wrapper 

Wrapper

neutral component
wrapper 

Wrapper

neutral component
Nrx-IV 

Nrx-IV

neutral component
Nrx-IV 

Nrx-IV

neutral component
Nrx-IV 

Nrx-IV

neutral component
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was live S2 cells; proteins produced from transfected constructs.

(Wheeler et al., 2009)

Physical interaction of proteins expressed on the surface of cells is inferred from the aggregation of live cells.

(Wheeler et al., 2009)
FBrf0207497-1.BA.FM
Reference
Stork et al., 2009
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
Nrx-IV 

Neurexin IV

neutral component
Nrx-IV 

Neurexin IV

neutral component
Nrx-IV 

Neurexin IV

neutral component
wrapper 

Wrapper

neutral component
wrapper 

Wrapper

neutral component
wrapper 

Wrapper

neutral component
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was live S2 cells; proteins produced from transfected constructs.

(Stork et al., 2009)

Physical interaction of proteins expressed on the surface of cells is inferred from the aggregation of live cells.

(Stork et al., 2009)
FBrf0213315-2.coIP.WB
Reference
Slováková and Carmena, 2011
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Nrx-IV 

Nrx-IV

bait

GFP tag

wrapper 

Wrapper

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was embryos of transgenic fly line; bait produced from tagged transgenic construct; prey produced from endogenous gene.

(Slováková and Carmena, 2011)

cno does not bind to Nrx-IV in this experiment.

(Slováková and Carmena, 2011)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (3)