FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
mod(mdg4), lolal
FlyBase ID
FBig0000111763
Interaction Network
Interactions Browser links
mod(mdg4) network
lolal network
Reported Interactions
FBrf0215054-26.Y2H
Reference
Bonchuk et al., 2011
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
mod(mdg4) 

Mod(mdg4)

bait

fused to GAL4 DNA-binding domain

mod(mdg4) 
mod(mdg4) 
lolal 

Batman

prey

fused to GAL4 activation domain

lolal 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
mod(mdg4) 
BTB domain
sufficient binding region
aa 1-119
lolal 
BTB domain
sufficient binding region
aa 1-128
mod(mdg4) 
N-terminal domain
necessary binding region
aa 1-18
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was yeast cell line; bait produced as transgenic fusion protein; prey produced as transgenic fusion protein (prey was previously cloned reagent).

(Bonchuk et al., 2011)

Two-hybrid system: yeast GAL4-BD/GAL4-AD

(Bonchuk et al., 2011)
FBrf0215054-32.Y2H
Reference
Bonchuk et al., 2011
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
lolal 

Batman

bait

fused to GAL4 DNA-binding domain

lolal 
mod(mdg4) 

Mod(mdg4)

prey

fused to GAL4 activation domain

mod(mdg4) 
mod(mdg4) 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
mod(mdg4) 
BTB domain
sufficient binding region
aa 1-119
lolal 
BTB domain
sufficient binding region
aa 1-128
mod(mdg4) 
N-terminal domain
necessary binding region
aa 1-18
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was yeast cell line; bait produced as transgenic fusion protein; prey produced as transgenic fusion protein (prey was previously cloned reagent).

(Bonchuk et al., 2011)

Two-hybrid system: yeast GAL4-BD/GAL4-AD

(Bonchuk et al., 2011)
FBrf0260563-47.Y2H
Reference
Bonchuk et al., 2024
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
mod(mdg4) 

mod(mdg4)

bait

fused to GAL4 DNA-binding domain

mod(mdg4) 
lolal 

Batman

prey

fused to GAL4 activation domain

lolal 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
mod(mdg4) 
TTK-type BTB domain
sufficient binding region
aa 1-77
lolal 
TTK-type BTB domain
sufficient binding region
aa 1-124

coordinates relative to lolal-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Two-hybrid system: yeast GAL4-BD/GAL4-AD

(Bonchuk et al., 2024)

Source was yeast cell line; bait produced as transgenic fusion protein; prey produced as transgenic fusion protein (prey was previously cloned reagent).

(Bonchuk et al., 2024)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)