FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
scrib, Nrx-1
FlyBase ID
FBig0000115740
Interaction Network
Interactions Browser links
scrib network
Nrx-1 network
Reported Interactions
FBrf0236511-1.coIP.WB
Reference
Rui et al., 2017
Description
physical association
Assay
Collection
Source/Stage
brain / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
scrib 

scribble

bait

GFP tag

Nrx-1 

DNRX

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was adult brains of transgenic fly line; bait produced from tagged transgenic construct; prey produced from endogenous gene.

(Rui et al., 2017)
FBrf0236511-3.PD.WB
Reference
Rui et al., 2017
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Nrx-1 

DNRX

bait

GST tag

Nrx-1 
Nrx-1 
scrib 

scribble

prey

HA, His tag

scrib 
scrib 
scrib 
scrib 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Nrx-1 
C-terminal domain
sufficient binding region
unspecified
Nrx-1 
PDZ-binding domain
necessary binding region
aa 1756-1837

coordinates relative to Nrx-1-PA

scrib 
PDZ1 domain
sufficient binding region
unspecified
scrib 
PDZ2 domain
sufficient binding region
unspecified
scrib 
PDZ3 domain
sufficient binding region
unspecified
scrib 
PDZ4 domain
sufficient binding region
unspecified
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey derived from transfected HEK293T cells.

(Rui et al., 2017)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)