FB2026_02 , released June 18, 2026
Physical Interaction report
Open Close
General Information
Interaction Type
physical association
Interacting Genes
Su(var)205, Polr2A
FlyBase ID
FBig0000116016
Interaction Network
Interactions Browser links
Su(var)205 network
Polr2A network
Reported Interactions
FBrf0209129-1.coIP.WB
Reference
Piacentini et al., 2009
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Su(var)205 

HP1a

bait
Polr2A 

PolII

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was unspecified; bait produced from endogenous gene; prey produced from endogenous gene.

(Piacentini et al., 2009)
FBrf0241416-36.coIP.WB
Reference
Lee et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
Su(var)205 

HP1a

bait

FLAG tag

Polr2A 

PolII

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Lee et al., 2019)
FBrf0241416-39.PD.WB
Reference
Lee et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Polr2A 

PolII

bait

biotin label

Su(var)205 

HP1a

prey

FLAG tag

Su(var)205 
Su(var)205 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Su(var)205 
Chromo domain
sufficient binding region
aa 1-140
Su(var)205 
Chromo domain
necessary binding region
aa 1-75
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait peptide chemically synthesized and labeled in vitro; prey produced as a recombinant fusion protein in baculovirus and Sf21 cell system.

(Lee et al., 2019)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)