FB2026_02 , released June 18, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
aop
FlyBase ID
FBig0000117159
Interaction Network
Interactions Browser links
aop network
Reported Interactions
FBrf0240614-1.CM.MW
Reference
Hope et al., 2018
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
aop 

yan

neutral component
aop 

yan

neutral component
aop 
aop 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
aop 
SAM domain
sufficient binding region
aa 33-117
aop 
SAM domain residues 92,93,96,97
mutation increasing interaction
aa 92,93,96,97

R92K,A93E,G96R,H97Y, mutations result in higher order aop polymers

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; protein produced as a recombinant fusion proteins in bacterial system.

(Hope et al., 2018)
FBrf0240614-2.SPR
Reference
Hope et al., 2018
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
aop 

yan

neutral component
aop 

yan

neutral component
aop 
aop 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
aop 
SAM domain
sufficient binding region
aa 33-117
aop 
SAM domain residues 92,93,96,97
mutation increasing interaction
aa 92,93,96,97

R92K,A93E,G96R,H97Y

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; protein produced as a recombinant fusion proteins in bacterial system.

(Hope et al., 2018)
FBrf0240614-3.coIP.WB
Reference
Hope et al., 2018
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
aop 

yan

bait

FLAG tag

aop 

yan

prey

HA tag

aop 
aop 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
aop 
SAM domain
sufficient binding region
aa 33-117
aop 
SAM domain residues 92,93,96,97
mutation increasing interaction
aa 92,93,96,97

R92K,A93E,G96R,H97Y

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Hope et al., 2018)
External Crossreferences and Linkouts ( 0 )
References (1)