FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
brp, Srpk79D
FlyBase ID
FBig0000118045
Interaction Network
Interactions Browser links
brp network
Srpk79D network
Reported Interactions
FBrf0241794-1.Y2H
Reference
Driller et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
brp 

BRP-190

unspecified role
brp 

BRP-190

unspecified role
brp 
brp 

BRP-190

unspecified role
brp 
Srpk79D 

SRPK79D

unspecified role
Srpk79D 
Srpk79D 

SRPK79D

unspecified role
Srpk79D 

SRPK79D

unspecified role
Srpk79D 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
brp 
N-terminal domain
sufficient binding region
aa 1-152

coordinates relative to brp-PG

Srpk79D 
Core domain
sufficient binding region
aa 327-869

coordinates relative to Srpk79D-PF

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was yeast cell line; bait produced as transgenic fusion protein; prey produced as transgenic fusion protein (prey was previously cloned reagent).

(Driller et al., 2019)

Two-hybrid system: yeast lexA-BD/GAL4-AD

(Driller et al., 2019)
FBrf0241794-2.CH.MW
Reference
Driller et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
brp 

BRP-190

neutral component
brp 

BRP-190

neutral component
brp 
brp 

BRP-190

neutral component
brp 
Srpk79D 

SRPK79D

neutral component
Srpk79D 
Srpk79D 
Srpk79D 

SRPK79D

neutral component
Srpk79D 

SRPK79D

neutral component
Srpk79D 
Srpk79D 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
brp 
N-terminal domain
sufficient binding region
aa 1-152

coordinates relative to brp-PG

Srpk79D 
Core domain
sufficient binding region
aa 327-869

coordinates relative to Srpk79D-PF

Srpk79D 
dock domain residues 758,774,781,825
mutation disrupting interaction
aa 758,774,781,825

D758A,D774A,E781A,K825A, coordinates relative to Srpk79D-PF

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; proteins produced as a recombinant fusion proteins in bacterial system.

(Driller et al., 2019)
FBrf0241794-3.PA
Reference
Driller et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
brp 

BRP-190

bait
brp 
Srpk79D 

SRPK79D

prey

GST tag

Srpk79D 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
brp 
N-terminal domain
sufficient binding region
aa 57-81aa 106-130

coordinates relative to brp-PG

coordinates relative to brp-PG

Srpk79D 
Core domain
sufficient binding region
aa 327-869

coordinates relative to Srpk79D-PF

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; proteins produced as a recombinant fusion proteins in bacterial system.

(Driller et al., 2019)
FBrf0241794-4.ENZ.A
Reference
Description
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Srpk79D 

SRPK79D

enzyme
Srpk79D 

SRPK79D

enzyme
Srpk79D 
Srpk79D 
brp 

BRP-190

enzyme target

P[32] label

brp 

BRP-190

enzyme target

P[32] label

brp 
brp 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction
External Crossreferences and Linkouts ( 0 )
References (1)