FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
Interacting Genes
FlyBase ID
FBig0000119881
Interaction Network
Interactions Browser links
Su(var)2-HP2 network
E(bx) network
Reported Interactions
FBrf0194422-1.CH.WB
Description
physical association
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note

HP2

neutral component

HP2

neutral component

HP2

neutral component

NURF301

neutral component

NURF301

neutral component

NURF301

neutral component
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was embryos of wild-type fly line; proteins produced from endogenous genes.

FBrf0194422-12.coIP.WB
Description
physical association
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note

HP2

bait

NURF301

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was embryos of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

FBrf0194422-8.coIP.WB
Description
physical association
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note

HP2

bait

NURF301

prey

FLAG tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
interaction domain
sufficient binding region
aa 1-276aa 2337-2512aa 2647-3027

coordinates relative to Su(var)2-HP2-PA

coordinates relative to Su(var)2-HP2-PA

coordinates relative to Su(var)2-HP2-PA

interaction domain
necessary binding region
aa 229-276aa 2337-2414aa 2647-3006

coordinates relative to Su(var)2-HP2-PA

coordinates relative to Su(var)2-HP2-PA

coordinates relative to Su(var)2-HP2-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced by in vitro translation; prey derived from immunopurified NURF complex.

External Crossreferences and Linkouts ( 0 )
References (1)