FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
mir-219, Fmr1
FlyBase ID
FBig0000120574
Interaction Network
Interactions Browser links
mir-219 network
Fmr1 network
Reported Interactions
FBrf0241216-1.miR-mRNA.LUC
Reference
Wang et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Kc167
Participants
Corresponds to
Reported as
Role
Note
mir-219 

miR-219

bait
Fmr1 

dfmr1

prey
Fmr1 
Fmr1 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Fmr1 
3-prime UTR
sufficient binding region
Fmr1 
mir-219 target sites
necessary binding region
ACAAUCA

two potential mir-219 binding sites simultaneously mutated, ACAAUCA to GCGGCCGC and ACAAUCA to CTCGAG

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Luciferase reporter assay.

(Wang et al., 2019)

Source was Kc167 cell line; bait produced from transfected construct; prey produced from transfected reporter construct.

(Wang et al., 2019)
FBrf0241216-3.miR-mRNA.PCR
Reference
Wang et al., 2019
Description
physical association
Assay
Collection
Source/Stage
head / third instar larval stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
mir-219 

miR-219

bait
Fmr1 

dFMRP

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Overexpression of mir-219 reduces Fmr1 protein levels.

(Wang et al., 2019)

Source was larval wing discs of transgenic fly line; bait produced from transgenic construct; prey produced from endogenous gene.

(Wang et al., 2019)
External Crossreferences and Linkouts ( 0 )
References (1)