FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
cic, mnb
FlyBase ID
FBig0000120663
Interaction Network
Interactions Browser links
cic network
mnb network
Reported Interactions
FBrf0246880-1.coIP.WB
Reference
Yang et al., 2016
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
cic 

Cic

bait

V5 tag

cic 
mnb 

Mnb

prey

HA tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
cic 
N-terminal domain
sufficient binding region
aa 1-453

coordinates relative to cic-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Yang et al., 2016)

The cic-mnb interaction is increased with overexpression of wap and decreased upon wap depletion.

(Yang et al., 2016)
FBrf0246880-4.coIP.WB
Reference
Yang et al., 2016
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
mnb 

Mnb

bait

RFP tag

cic 

Cic

prey

GFP tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was embryos of transgenic fly line; bait produced from tagged transgenic construct; prey produced from tagged transgenic construct.

(Yang et al., 2016)
FBrf0246880-7.coIP.MS
Reference
Yang et al., 2016
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
cic 

Cic

bait

SBP tag

mnb 

Mnb

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Yang et al., 2016)
External Crossreferences and Linkouts ( 0 )
References (1)