FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Hecw, Fmr1
FlyBase ID
FBig0000121418
Interaction Network
Interactions Browser links
Hecw network
Fmr1 network
Reported Interactions
FBrf0251317-42.coIP.WB
Reference
Fajner et al., 2021
Description
physical association
Assay
Collection
Source/Stage
ovary / femaleadult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Hecw 

Hecw

bait
Fmr1 

Fmr1

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was ovaries of a wild type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

(Fajner et al., 2021)
FBrf0251317-43.ENZ.WB
Reference
Description
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Hecw 

Hecw

enzyme

GST tag

Hecw 

Hecw

enzyme

GST tag

Fmr1 

Fmr1

enzyme target

His-MBP tag

Fmr1 

Fmr1

enzyme target

His-MBP tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction
FBrf0251317-6.PD.MS
Reference
Fajner et al., 2021
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
Hecw 

Hecw

bait

GST tag

Hecw 
Fmr1 

Fmr1

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Hecw 
WW domains residues 636-834
sufficient binding region
aa 636-834
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced as a recombinant fusion protein in bacterial system; prey derived from S2 cell extract.

(Fajner et al., 2021)
External Crossreferences and Linkouts ( 0 )
References (1)