FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Nup98-96, His2Av
FlyBase ID
FBig0000123998
Interaction Network
Interactions Browser links
Nup98-96 network
His2Av network
Reported Interactions
FBrf0262696-3.PLA
Reference
Merigliano et al., 2025
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Kc167
Participants
Corresponds to
Reported as
Role
Note
Nup98-96 

Nup98

neutral component

GFP tag

Nup98-96 
Nup98-96 

Nup98

neutral component

GFP tag

Nup98-96 
Nup98-96 

Nup98

neutral component

GFP tag

His2Av 

ggr;-H2Av

neutral component
His2Av 

ggr;-H2Av

neutral component
His2Av 

ggr;-H2Av

neutral component
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Nup98-96 
Nucleoporin Nup98 FG repeat region
sufficient binding region
aa 1-481
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was was Kc167 cell line; Nup98-96 produced from transgenic construct; His2Av produced from endogenous gene.

(Merigliano et al., 2025)

Nucleoporin 98-96kD (Nup98-96) encodes a precursor protein that is cleaved into Nup98 and Nup96 proteins. RNAi of mbo, Sec13 or both disrupts Nup98-His2Av interaction.

(Merigliano et al., 2025)
External Crossreferences and Linkouts ( 0 )
References (1)