Wu, C. (1984). Two protein-binding sites in chromatin implicated in the activation of heat-shock genes.  Nature 309(): 229--234.

FBrf0041540

Research paper

The resistance to exonuclease digestion of two regions of chromatin at the 5' end of heat-shock genes in Drosophila implies they have protein bound to them. The pattern of resistance before and after induction of gene expression suggests that heat-shock genes are activated by the sequential binding of at least two protein factors.