Subject: ADRC: 105
Dear Julie,
I am writing in connection with your abstract for the upcoming Washington
DC ADRC:
'Ring canal morphogenesis in the male germ line.'
You mention a gene, 'separation-anxiety', that is new to FlyBase. Do you
have a symbol or a map location for this gene? It is nice if we can keep
as many gene records as possible anchored to the map.
Thank you for your help,
with best wishes,
Rachel.
Subject: Re: ADRC: 105
Hi Rachel,
separation anxiety (abbreviation yet to be determined - suggestions
appreciated) is a new mutation identified from a screen for male sterile
mutations conducted by Barbara Wakimoto et al. (see abstract number 106).
I do not know the map position (you could get that information from Minx),
but the mutation is located on chromosome 2.
	There is another gene (also from Barbara Wakimoto's male sterile
screen), provisionally called 'four way stop' (abbrev. fws) that has a
similar phenotype and has also been characterized and mapped by Rebecca
and Cricket. It is also on chromosome 2 and is uncovered by a deficiency.
There is one allele of separation anxiety and there are two alleles of
fws. The phenotype for mutations in both of these genes is a failure in
meiotic cytokinesis ('four wheel drive' phenotype), as well as a failure
in proper polarization and bundling of the cysts of elongating spermatids.
The end result is an accumulation of ovoid cysts containing multinucleate
spermatids. The flies are male sterile.
	Hope this helps.
						Sincerely,
						Julie Brill
P.S. I am forwarding a copy of this to Minx and also to Cricket in case
either of them has time to provide additional information.
Subject: fwd like mutants
Hi Minx, Julie and Rachel,
	I was away when you sent the emails about the fwd mutants. Here is the
latest mapping information on them.
12-41 'separation anxiety' maps between al and dp by recombination and to
22D5-E1; 22F2 or 23C or 23E3-6;24A3-4 by deficiency
Hope all this information is helpful!
Cricket Wood
Fuller Lab RA