Subject: ADRC-560A
Dear Makoto,
We are currently curating the abstracts for the upcoming Bellevue
(Seattle) Annual Drosophila Research Conference, for FlyBase. I am
writing in connection with your abstract:
'Analysis of Alzheimer related genes in Drosophila.'
You mention two genes that are new to FlyBase, X11L and dp1.
Do you have map locations for X11L and dp1? It is nice if we can keep
as many gene records as possible anchored to the map.
You say 'One clone tentatively named dp1..' Have you settled on a
symbol/name for dp1 yet?
Is X11L related to Human XLL, now known as APBA1?
I realise that you are neither the first nor the last author for this
abstract - however you are the only author whose contact information is
in FlyBase. Feel free to pass this query on to one of the other
authors, if that is more appropriate.
Thank you for your help,
with best wishes,
Rachel.
Subject: Re: ADRC-560A
Dear Dr Drysdale
I have forwarded your e-mail for Dr Nakamura.
I'm first author for the abstract.
I answer your questions.
dp1 is on 61F. Near Klp61F. We are trying to determine X11L locus but we
have not
determined yet. We can determine the X11L locus soon.
>> You say 'One clone tentatively named dp1..' Have you settled on a
>> symbol/name for dp1 yet?
We have not. We do not found known mutation on 61F as dp1 mutant.
>>
>> Is X11L realted to Human XLL, now known as APBA1?
>>
Following to recent nomenclature, X11L is called APBA2. We used human APBA2 cDNA
as a probe for screening. dX11L has homology with both APBA1 and 2 in PID
(PTD) and
PDZ domain. N terminal region homology is low. We don't have another clone
and we cannot
conclude dX11L is APBA1 homolog or APBA2 homolog, or only one homolog gene
in fly.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
Yoshimasa Yagi, PhD.
Laboratory of Neurobiophysics
School of Pharmaceutical Sciences
The University of Tokyo
Hongo, Bunkyo-ku, Tokyo 113-0033
Japan
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