Gene or accession: CG7689
Gene annotation error
Gene fru has incorrect exon/intron structure.
Comments: fru turns out to be a complex alternatively spliced protein so I
have tried to be
as explicit as possible in this update \- I hope I have succeeded.
Current Celera entry for fru:
AE003722; AAF55564.1
is OK but annotation is missing 4 further isoforms.
AE003722; AAF55564.1 translation starts at the female init Met (as defined by
Ryner et al, Cell  87:1079-1089 (1996) through to C terminal stop codon.
Published cDNAs from Ryner et al
AF039231; AAB96677.1
U72492; AAB92662.1
correspond to male and female isoforms with a different C terminus. This C
terminus is present in the Celera sequence (didn't work out coordinates, sorry)
so both isoforms should be annotated.
At this stage there should be three isoforms.
The male exon, as defined by Ryner et al, is present in Celera as a separate
gene
CG7690. This exon does not exist as a gene in its own right so CG7690 should be
merged with fru and the CDS feature editted to splice the exon onto the CDS
feature
of Celera fru isoform (AE003722; AAF55564.1)
CDS = complement(129673-129961) complement(50192-50339) ..then continue as is
already
annotated in the CDS feature.
This CDS feature defines the intron and removes the stop codon of CG7690.
At this stage there should be four isoforms.
Finally, one further group isolated fru and defined a further isoform with a
third
unique C terminus. Again this translation is present in Celere sequence so
should be
annotated (again I have no coordinates), note there is one conflict in the
translation
between Celera and published sequence.
The isoform sequence is in D84437; BAA12663.1, Ito et al, Proc. Natl. Acad. Sci.
U.S.A.  93:9687-9692 (1996).
Now you should have 5 isoforms and I know of no further isoforms from the
literature.
thank you!