Subject: FlyBase query: dHDAC4
Dear Dr. O'Connor,
I am a curator working for FlyBase.
it was pointed out to us by a user, that the gene referred to as
'dHDAC4' in an abstract of yours may be the same as one of the
predicted 'CG' genes in FlyBase.
The abstract is:
Mallin et al., 2000, A. Dros. Res. Conf. 41: 203A
'Genetic analysis of the Drosophila histone deacetylase dHDAC2.'
In this, you state that 'dHDAC4' maps to 11F-12A.
The predicted histone deacetylase is CG1770 (FBgn0030464), which is
inferred to map to 11E1--3 from its position in the genomic sequence.
This gene has homology to human 'histone deacetylase 4'.
Do you know whether your 'dHDAC4' is the same as CG1770 \- if that is
the case, then I can merge the two genes in the database (I would record
this information as a personal communication from you to FlyBase),
I look forward to hearing from you,
Gillian
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Gillian Millburn.
FlyBase (Cambridge),
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Subject: HDAC4
Dear Gillian,
My name is Doug Bornemann and I am working as a post doc in the O'Connor
lab. You recently requested information about whether dHDAC4 on one of
our abstracts corresponded with CG1770 which has homology to human HDAC4.
Indeed our drosophila HDAC4 corresponds to CG1770, based on our sequencing
of a dHDAC4 cDNA. The cDNA has some minor differences from the predicted
sequence, and we are still working or resolving some ambiguities, which
should be done soon.
If you need any more information, let me know.
Doug Bornemann