The following information was provided by Charles Sackerson on January 17 2001 in response to a curator query regarding the Adam and Apple genes: "CG12131 is "Adam" -- the sequence gives strong matches to eIF3. Although the end-points differ from those indicated by restriction maps of embryonic cDNAs, they are close, and intron-exon boundaries agree with the cDNAs. The 5' end maps to a constitutive DNaseI hypersensitive site. The region has been sequenced from a second species (Idiomyia grimshawi; Genbank U39659). The next gene, CG12134, was not detected in embryonic cDNAs (0-18 hr, Clontech). Both end-points map to constitutive hypersensitive sites, however. The predicted transcript overlaps an enhancer with pair-rule expression which has been proposed to be a redundant even-skipped late element. The predicted protein gives poor matches to other known proteins. The 5' end of eve is not predicted correctly; it has been mapped to nt131401. The 3' end (poly-A) and intron-exon boundaries are correct. Ter94 is the same as the transcript previously described as "Apple". The predicted 5' end is close to that indicated by sequences available in Genbank (AF047037 and AF202034), and maps to a DNaseI hypersensitive site found in embryos, adults, and S2 cells."