Open Close
Reference
Citation
Mason, J.M., Haoudi, A., Konev, A.Y., Kurenova, E., Walter, M.F., Biessmann, H. (2000). Control of telomere elongation and telomeric silencing in Drosophila melanogaster.  Genetica 109(1-2): 61--70.
FlyBase ID
FBrf0135797
Publication Type
Research paper
Abstract

Chromosome length in Drosophila is maintained by the targeted transposition of two families of non-LTR retrotransposons, HeT-A and TART. Although the rate of transposition to telomeres is sufficient to counterbalance loss from the chromosome ends due to incomplete DNA replication, transposition as a mechanism for elongating chromosome ends raises the possibility of damaged or deleted telomeres, because of its stochastic nature. Recent evidence suggests that HeT-A transposition is controlled at the levels of transcription and reverse transcription. HeT-A transcription is found primarily in mitotically active cells, and transcription of a w+ reporter gene inserted into the 2L telomere increases when the homologous telomere is partially or completely deleted. The terminal HeT-A array may be important as a positive regulator of this activity in cis, and the subterminal satellite appears to be an important negative regulator in cis. A third chromosome modifier has been identified that increases the level of reverse transcriptase activity on a HeT-A RNA template and greatly increases the transposition of HeT-A. Thus, the host appears to play a role in transposition of these elements. Taken together, these results suggest that control of HeT-A transposition is more complex than previously thought.

PubMed ID
PubMed Central ID
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetica
    Title
    Genetica
    Publication Year
    1919-
    ISBN/ISSN
    0016-6707
    Data From Reference
    Aberrations (1)
    Alleles (2)
    Genes (8)
    Natural transposons (2)
    Insertions (3)
    Transgenic Constructs (3)