Gene or accession: CG1004
Release: 2
Missed gene
Comments: Although the precise role of Rhomboid in triggering EGF receptor
signalling has remained elusive, we have now determined its mechanism.
Rhomboid-1 is an intramembrane serine protease that cleaves the three
TGFa-like EGF ligands in Drosophila, thus activating them as signals. The
cleavage occurs within their transmembrane domains. Rhomboid-1 is localized
in the Golgi apparatus, and this is the compartment where cleavage of the
ligand occurs (not at the plasma membrane). The other fly Rhomboids (2,3, and
4) are also intramembrane serine proteases that catalyze the proteolytic
release of these ligands. This work is published in the following articles:
Urban, S, Lee J. R., and M. Freeman. Drosophila Rhomboid-1 defines a family
of putative
intramembrane serine proteases. (2001). Cell 107: in press <up>Oct 19th issue</up>.
Lee J. R., Urban, S, Garvey C. F., and M. Freeman. Regulated intracellular
transport and proteolysis control EGF ligand activation in Drosophila. (2001).
Cell 107: in press <up>Oct 19th issue</up>.