FlyBase Gene Report: Dmel\stet

General Information

Symbol

Dmel\stet

Species

D. melanogaster

Name

stem cell tumor

Annotation Symbol

CG33166

Feature Type

protein_coding_gene

FlyBase ID

FBgn0020248

Gene Model Status

Current

Stock Availability

9 publicly available

Enzyme Name (EC)

Gene Summary

stem cell tumor (stet) encodes a gonad-specific intra-membrane protease of the rhomboid family that activates ligands of the product of Egfr. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

rhomboid-2, rho-2, brho

Key Links

Genomic Location

Cytogenetic map

62A2-62A2

Sequence location

3L:1,475,438..1,489,547 [-]

Recombination map

3-0.5

RefSeq locus

NT_037436 REGION:1475438..1489547

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables serine-type endopeptidase activity

inferred from direct assay

(Ghiglione et al., 2002, Urban et al., 2002)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR002048

(InterPro Project Members, 2004-)

enables serine-type endopeptidase activity

inferred from biological aspect of ancestor with PANTHER:PTN000533014

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR017213, InterPro:IPR022764

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR022764

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in epidermal growth factor receptor ligand maturation

inferred from direct assay

(Ghiglione et al., 2002, Urban et al., 2002)

inferred from genetic interaction with FLYBASE:grk; FB:FBgn0001137,FLYBASE:spi; FB:FBgn0005672

(Guichard et al., 2000)

inferred from genetic interaction with FLYBASE:S; FB:FBgn0003310

(Yogev et al., 2008)

involved_in male germ-line stem cell population maintenance

inferred from genetic interaction with UniProtKB:A1YK24,UniProtKB:Q9VCH5,UniProtKB:Q9VCH5

(Parrott et al., 2011)

involved_in protein processing

inferred from direct assay

(Ghiglione et al., 2002, Urban et al., 2002)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in Golgi apparatus

inferred from direct assay

(Ghiglione et al., 2002)

located_in Golgi membrane

inferred from direct assay

(Urban et al., 2002)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR017213, InterPro:IPR022764

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR022764

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

RHOMBOID PROTEASES

Pathway (FlyBase)

EGFR LIGAND PRODUCTION

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

serine-type endopeptidase activity

Summaries

Gene Snapshot

stem cell tumor (stet) encodes a gonad-specific intra-membrane protease of the rhomboid family that activates ligands of the product of Egfr. [Date last reviewed: 2019-03-14]

Pathway (FlyBase)

EGFR LIGAND PRODUCTION -: Factors required for the proteolytic cleavage and/or secretion of transforming growth factor-α-like Egfr ligands spi, Krn or grk.

Gene Group (FlyBase)

RHOMBOID PROTEASES -: Rhomboid proteases are intramembrane serine proteases related to rho, that cleave other transmembrane proteins within their transmembrane domains. Rhomboid proteases are best characterized for their role in epidermal growth factor signaling, where they are required for the production the soluble, secreted ligand. They belong to MEROPS family S54. (Adapted from FBrf0235672).

Summary (Interactive Fly)

Rhomboid-related transmembrane protein - serine-type protease - activates the oocyte-specific Gurken ligand and thereby participate in defining posterior cell fates in the early follicular epithelium

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\stet for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W0E9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene merge/split based on EST data.

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

stet-RA

FBtr0072713

NM_176273

1898

330

stet-RB

FBtr0072712

NM_176272

2380

485

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

stet-PA

FBpp0072597

37.1

330

6.99

FBpp0072596

54.5

485

5.96

Q9W0E9

NP_788450

AAF47499

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\stet using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.13

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in Golgi apparatus

inferred from direct assay

(Ghiglione et al., 2002)

located_in Golgi membrane

inferred from direct assay

(Urban et al., 2002)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\stet in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\stet

View exonic expression by tissue for Dmel\stet

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38169/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0020248

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0020248

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0020248

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33166

Flygut - An atlas of the Drosophila adult midgut

FBgn0020248

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 28 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of stet

Transgenic constructs containing regulatory region of stet

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Df(3L)29b

(Schulz et al., 2002)

Df(3L)PX62

(Schulz et al., 2002)

Gene not disrupted in

Df(3L)49-15

(Schulz et al., 2002)

Gene partially disrupted in

Df(3L)stet^1A3

(Liu et al., 2010)

Inferred from location ( 9 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

stet^GD2244

viable, with Scer\GAL4^Mef2.PR

stet^GD2244

viable, with Scer\GAL4^pnr-MD237

stet^GD2244

viable, with Scer\GAL4^tin.CΔ4

stet^GD2244

Sterility

Allele

female sterile | recessive

stet^1A3

fertile

stet^EY07108

male sterile

Other Phenotypes

Allele

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

stet^GD2244

Phenotype manifest in

Allele

cyst cell of testis (with Df(3L)PX62)

stet⁸⁷¹

dorsal appendage, with Scer\GAL4^CY2

stet^UAS.cGa

egg chamber (with Df(3L)PX62)

stet⁸⁷¹

egg chorion, with Scer\GAL4^CY2

stet^UAS.cGa

female germline stem cell (with Df(3L)PX62)

stet⁸⁷¹

germarium

stet^1A3

germarium | germline clone

stet^1A3

hub cell (with Df(3L)PX62)

stet⁸⁷¹

male germline cell

stet¹

male germline stem cell (with Df(3L)PX62)

stet⁸⁷¹

male germline stem cell | germline clone

stet^unspecified

ovarian sheath cell (with Df(3L)PX62)

stet⁸⁷¹

ovariole (with Df(3L)PX62)

stet⁸⁷¹

spectrosome | germline clone | increased number

stet^1A3

spectrosome | increased number

stet^1A3

testis (with Df(3L)PX62)

stet⁸⁷¹

testis | germline clone

stet^unspecified

wing, with Scer\GAL4^Bx-MS1096

stet^UAS.cUa

wing vein | ectopic, with Scer\GAL4^Bx-MS1096

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (7)

Hsap\RHBDL3

12 of 14

Yes

Hsap\RHBDL1

10 of 14

Yes

Hsap\RHBDL2

5 of 14

Yes

3 of 14

3 of 14

2 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (7)

Rnor\Rhbdl3

13 of 14

Yes

Rnor\Rhbdl1

5 of 14

Yes

4 of 14

3 of 14

3 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (7)

Mmus\Rhbdl3

13 of 14

Yes

Mmus\Rhbdl1

10 of 14

Yes

Mmus\Rhbdl2

5 of 14

Yes

3 of 14

3 of 14

2 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (7)

Xtro\rhbdl3

7 of 13

Yes

Xtro\rhbdl1

5 of 13

Yes

Xtro\rhbdl2

4 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (9)

Drer\rhbdl3

12 of 14

Yes

Drer\rhbdl1

10 of 14

Yes

6 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\rom-1

9 of 14

Yes

Cele\rom-2

7 of 14

Yes

Cele\rom-3

3 of 14

Cele\rom-4

2 of 14

Cele\rom-5

1 of 14

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP005058

12 of 12

Yes

4 of 12

3 of 12

2 of 12

2 of 12

Arabidopsis thaliana (thale-cress) (14)

Atha\KOM

5 of 13

Yes

Atha\RBL1

5 of 13

Yes

Atha\RBL2

5 of 13

Yes

Atha\RBL3

5 of 13

Yes

Atha\RBL4

5 of 13

Yes

Atha\RBL5

5 of 13

Yes

Atha\RBL6

5 of 13

Yes

Atha\RBL7

5 of 13

Yes

Atha\AT5G38510

3 of 13

Yes

Atha\RBL10

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\PCP1

2 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\SPBC13E7.11

1 of 12

Yes

Spom\SPBP4H10.10

1 of 12

Yes

Escherichia coli (enterobacterium) (1)

Ecol\glpG

2 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:stet. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

rho-6

8 of 13

rho

8 of 13

rho-4

7 of 13

rho-5

5 of 13

rho-7

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RHBDL3; rhomboid like 3

12 of 14

619017

RHBDL1; rhomboid like 1

10 of 14

603264

RHBDL2; rhomboid like 2

5 of 14

608962

RHBDF1; rhomboid 5 homolog 1

3 of 14

614403

RHBDF2; rhomboid 5 homolog 2

3 of 14

614404

TYLOSIS WITH ESOPHAGEAL CANCER; TOC

palmoplantar keratoderma-esophageal carcinoma syndrome

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

stet - Krn

inferred by author, enzymatic study, anti tag western blot

(Urban et al., 2002)

stet - grk

inferred by author, enzymatic study, anti tag western blot

(Urban et al., 2002)

stet - spi

inferred by author, enzymatic study, anti tag western blot

(Urban and Freeman, 2003, Urban et al., 2002)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Liu et al., 2010)

suppressible

(Liu et al., 2010)

enhanceable

(Ghiglione et al., 2002, Guichard et al., 2000)

suppressible

(Liu et al., 2010)

suppressible

(Liu et al., 2010)

suppressible

(Schulz et al., 2002)

stet

suppressible

(Guichard et al., 2000)

stet

enhanceable

(Guichard et al., 2000)

stet

suppressible

tkv

(Liu et al., 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

grk

enhanceable

stet

(Ghiglione et al., 2002)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

63709

DroID - A comprehensive database of gene and protein interactions.

FBgn0020248

MIST (genetic) - An integrated Molecular Interaction Database

38169

MIST (protein-protein) - An integrated Molecular Interaction Database

38169

Pathways

Signaling Pathways (FlyBase)

EGFR LIGAND PRODUCTION

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-0.5

Cytogenetic map

62A2-62A2

Sequence location

3L:1,475,438..1,489,547 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

62A2-62A2

Limits computationally determined from genome sequence between P{EP}rho^EP3704&P{PZ}l(3)06226⁰⁶²²⁶ and P{PZ}dlt⁰⁴²⁷⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

62A1-62A1

(Freeman, 2000.11.2)

Experimentally Determined Recombination Data

Location

3-0.5

(FlyBase, 2016)

3-2.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

(Schulz et al., 2002)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

97856

w¹¹¹⁸; P{UAS-stet.gRNAx3.pCFD6}attP1/CyO

43060

y¹ w^*; Mi{MIC}stet^MI06389

16004

y¹ w^67c23; P{EPgy2}stet^EY08201

17375

y¹ w^67c23; P{EPgy2}stet^EY07108

67466

y¹ w^*; Mi{Trojan-GAL4.0}stet^{MI06389-TG4.0}

57698

y¹ sc^* v¹ sev²¹; P{TRiP.GLC01864}attP2

Kyoto

126078

w¹¹¹⁸; P{RS5}stet^5-SZ-3468

VDRC

v7434

w¹¹¹⁸; P{GD2244}v7434

v7435

w¹¹¹⁸; P{GD2244}v7435/TM3

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (76)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_RE60377

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0020248

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0020248

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Somatic support cells fail to surround germ cells properly and germ cells accumulate at early stages of differentiation in stet mutants.

(Schulz et al., 2002)

Mutations affect the early stages of differentiation in the male germline.

(Schulz and Fuller, 1997)

Relationship to Other Genes

Source for database merge of

Source for merge of: rhomboid-2 CG12083

(Wasserman et al., 2000)

Source for merge of: stet rho-2

(Schulz et al., 2002)

Source for merge of: rho-2 CG12504

(FlyBase Genome Annotators, 2002-2003)

Additional comments

3' exon of release 2 annotation CG12083 split into a new gene (CG32319) in release 3 of the genome annotation, while the 5' portion of CG12083 corresponds to part of stet (CG33166). In addition, the release 3 annotation for stet (CG33166) contains sequences corresponding to release 2 annotation CG12504.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

B-Rho

(Castro et al., 2007)

Brho

(Shilo, 2003)

CG12083

(Kai et al., 2005)

CG12504

CG33166

(Jayakumar et al., 2016, Ni et al., 2010.12.1)

Rho-2

(Yogev et al., 2008, Yogev et al., 2008, Yogev et al., 2007, Urban et al., 2002)

Rho2

(Shilo, 2003)

Stet

(Powles and Ko, 2018, Yamashita et al., 2010)

brho

(Ghiglione et al., 2002, Guichard et al., 2000)

rho-2

(Jiang and Edgar, 2009, Dworkin and Gibson, 2006, Giot et al., 2003, Wasserman et al., 2000)

rho2

(Jiang et al., 2011)

Name Synonyms

Stem cell tumor

(Eliazer and Buszczak, 2011, Liu et al., 2010)

brother of rhomboid

(Guichard et al., 2000)

rhomboid-2

(Dworkin and Gibson, 2006, Urban, 2006, Urban et al., 2004, Urban and Freeman, 2003, Klambt, 2000, Wasserman et al., 2000)

rhomboid2

(Shilo, 2016)

stem cell tumor

(Castro et al., 2007, Schulz and Fuller, 1997)

Secondary FlyBase IDs

FBgn0035221
FBgn0035223
FBgn0041725
FBgn0053166

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 57 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38169

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W0E9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W0E9

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38169/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0020248

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0020248

FlyMine - An integrated database for Drosophila genomics

FBgn0020248

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG33166

MARRVEL_MODEL - MARRVEL (model organism gene)

38169

Linkouts

BioGRID - A database of protein and genetic interactions.

63709

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0020248

DroID - A comprehensive database of gene and protein interactions.

FBgn0020248

DRSC - Results frm RNAi screens

FBgn0020248

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0020248

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0020248

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33166

Flygut - An atlas of the Drosophila adult midgut

FBgn0020248

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034044

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

38169

MIST (protein-protein) - An integrated Molecular Interaction Database

38169

References (91)

The following external sites may use different assemblies or annotations than FlyBase.

0.13

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