Subject: Helping FlyBase: ADRC-10421
Dear Kim,
We are currently curating the abstracts for the upcoming 43rd
(San Diego) Annual Drosophila Research Conference, for FlyBase.
I am writing in connection with your abstract:
'The Drosophila blue cheese Gene Identifies a Novel Progressive Neural
Degenerative Pathway.'
You mention a gene that is new to FlyBase, bchs. Do you know which of the
Genome Project CG annotations your gene corresponds to? All the CGs
have corresponding gene records in FlyBase already and we don't like to
make duplicate records for what is actually the same gene unless we
can't avoid it. If your gene does not correspond to a CG then perhaps
you could tell me its map location, as this is valuable information for
the genome annotation project.
Thank you very much for your help,
with best wishes,
Rachel.
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Rachel Drysdale, Ph.D.
FlyBase (Cambridge),
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Subject: Re: Helping FlyBase: ADRC-10421
>Dear Rachel,
I'm sorry for the confusion. There is a Flybase record for a portion
of the blue cheese gene noted as CG9011, map location 26A1. This is
a very long story but part of the confusion comes from our difficulty
in publishing our results on the entire gene, gene family and mutant
phenotype. The the beach1 gene as characterized in Flybase is
missing 5' and 3' exons making it an incomplete message. Added to
the carboxy terminus of BCHS is a motif that makes it distinct from
others containing beach domains (i.e.lyst). We have identified other
BCHS proteins from worms to humans making this a unique protein
sub-family.
The blue cheese name characterizes the mutant phenotype in which
there is progressive development of protein inclusions throughout the
adult CNS. We were following the swiss cheese example of naming
neurodegeneration mutants (i.e. progressive development of vacuoles
or holes in the adult CNS). We have four independent mutant alleles
(EP2299 included) all showing different degrees of the phenotype.
... I hope this clarifies everything....
Kim Finley