Subject: Helping FlyBase: ADRC-10823
Dear Tamara,
We are currently curating the abstracts for the upcoming 43rd
(San Diego) Annual Drosophila Research Conference, for FlyBase.
I am writing in connection with your abstract:
'Drosophila homologue of C. elegans unc-45: a novel myosin interacting
protein.'
You mention a gene that is new to FlyBase, unc-45. Do you know which of the
Genome Project CG annotations your gene corresponds to? All the CGs
have corresponding gene records in FlyBase already and we don't like to
make duplicate records for what is actually the same gene unless we
can't avoid it. If your gene does not correspond to a CG then perhaps
you could tell me its map location, as this is valuable information for
the genome annotation project.
You say 'We have obtained a strain that carries a P-element insertion
500 base pairs upstream of this coding region'. Is this one of the
BDGP insertions? If so we will already have a record for the insertion
so please could you let me know which one it is, so that I can keep all
the data properly inter-related. If this element is affecting unc-45
(your abstract suggests that it does) then I will make an allele of
unc-45 to reflect that.
Thank you very much for your help,
with best wishes,
Rachel.
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Rachel Drysdale, Ph.D.
FlyBase (Cambridge),
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Subject: RE: Helping FlyBase: ADRC-10823
Rachel,
the CG number is CG2708 (FlyBase ID: FBgn0010812) and the gene is
currently called Tom 34, this implies a mitochondrial localization. We
believe CG2708 is more likely to represent a homologue of Unc-45 in C.elegans.
This is a cytoplasmicly localized protein involved in muscle formation in the
nematode. We will be presenting evidence at the meeting. Sorry for any
confusion.
Tamara