Gene or accession: CG7190
Release: 2
Gene annotation error
Genes CG7190 and CG7193 and CG7195 should be merged.
Comments: We have recently published a paper (cited below), in which we
strongly suggest that CG7190, CG7193, and CG7195 are actually parts of a
single gene for an insect homologue of the vertebrate Golgi apparatus protein
1 (MG-160/cysteine-rich fibroblast growth factor receptor/E-selectin
ligand-1/latent transforming growth factor-beta complex protein-1). It is
supported by the following evidence: 1) Three and two of peptide fragments
from a Spodoptera glycoprotein showed high sequence homologies to CG7190 and
CG7193, respectively. 2) It was strongly suggested that the Spodoptera
glycoprotein was a membrane-bound protein. Although CG7190 and CG7193 could
not encode any membrane-spanning domains, but CG7195 could do one. 3)
Furthermore, 5' and 3' ESTs of LD19434 correspond to a part of CG7190 and a
region downstream from CG7195, respectively. 4) The possible single gene
containing these three genes could encode a polypeptide highly homologous to
the vertebrate GLG1 proteins.
Jun-ichi Kawano, Tatsuo Nakayama, Tomio Kotani, Hiroshi Matsubayashi,
Masa-Toshi Yamamoto, Tatsuo Suganuma: Identification and characterization of
an insect homologue of the vertebrate Golgi apparatus protein 1
(MG-160/cysteine-rich fibroblast growth factor receptor/E-selectin
ligand-1/latent transforming growth factor-beata complex protein-1) with a
Golgi-specific monoclonal antibody. Histochem Cell Biol, DOI
10.1007/s00418-002-0402-6. URL: http://dx.doi.org/10.1007/s00418-002-0402-6