Lohi, O., Poussu, A., Mao, Y., Quiocho, F., Lehto, V.P. (2002). VHS domain - a longshoreman of vesicle lines. FEBS Lett. 513(1): 19--23.
FlyBase ID
FBrf0149609
Publication Type
Review
Abstract
The VHS (Vps-27, Hrs and STAM) domain is a 140 residue long domain present in the very NH2-terminus of at least 60 proteins. Based on their functional characteristics and on recent data on the involvement of VHS in cargo recognition in trans-Golgi, VHS domains are considered to have a general membrane targeting/cargo recognition role in vesicular trafficking. Structurally, VHS is a right-handed superhelix of eight helices with charged surface patches probably serving as sites of protein-protein recognition and docking.
