File date: 2002.11.11 ; File size: 205970 ; File format: fasta ; File name: kinbase_fly_protein_sequences.fasta
Subject: RE: where is the Drosophila file ?
Hi Michael,
	You're certainly welcome to add the annotation and point to
kinase.com as a temporary reference source - I'm only sorry that I haven't
had the chance to go further on that myself. I am hoping to submit a
shortish paper on the Drosophlia kinome, which is half-written but hasn't
made much progress recently (the human kinome paper is coming out in
December, in Science, and is still taking a lot of time, and we're in the
middle of the Pharmacia-Pfizer merger, so there are lots of distractions!).
I also haven't forgotten that I owe you some time working on the potential
of more detailed GO assignments to kinases...
	BTW the CG10673, annotated as a endopeptidase probably is a kinse:
it's a a homolog of human PRPK and yeast Bud32, all of which have weak but
detectable similarity to the kinase domain.
	The other information that I would love to get in flybase and other
databases concerns the classification and 'orthology' groups that we have
constructed for all kinases: using the sub-family classification, we can
often find  1:1  orthologs between genomes, and more often see  1:N  mappings
which are well curated and much better than most blast-based connections.
The family memberships are all available at kinase.com (the human ones will
be added on Dec 6), but we can also do work at our end to make the data more
palatable. Have there been any discussions with the other model organism
databases at trying to link putative orthologs?
	All the best,
		-Gerard.
-----Original Message-----
Sent: Wednesday, November 13, 2002  9:16  AM
Subject: RE: where is the Drosophila file ?
Gerard
I have downloaded the fasta file of kinase sequences from yr web site.
The following genes are not annotated as having the function 'protein
kinase'
in FlyBase.  I wonder if I could add this annotation from your data and, if
so, can you give me a suitable way to reference it ?
Best
Michael
=======================
 BcDNA:LD22679 
CG10673
 .. annotated as: metalloendopeptidase ; GO:0004222 ; EC:3.4.24.- | inferred
from sequence similarity with SWISS- PROT:O27476 
CG11660
CG11859
CG14163
CG1951
CG1973
CG2905
CG30078
CG3008
CG3608
CG4041
CG4410
CG4523
CG4588
CG7156
CG7616
CG8726
Slob
Taf250
fs(1)h
----- End Included Message -----
http://kinase.com/kinbase/FastaFiles/
fly_protein_sequences.fasta   11-Nov-2002  18:07    201k 
<up>see Associated file kinbase_fly_protein_sequences.fasta</up>