Rosenzweig, M., Garrity, P. (2002). Axon targeting meets protein trafficking: comm takes Robo to the cleaners.  Dev. Cell 3(3): 301--302.

FBrf0151896

Review

Axon guidance at the Drosophila midline relies on dynamic regulation of the guidance receptor Robo by its negative regulator Comm. Recent findings demonstrate that Comm collaborates with the ubiquitin-protein ligase DNedd4 to inhibit Robo signaling by promoting the sorting of Robo into the endocytic pathway.