Gene or accession: CG12864
Release: 3
Gene annotation error
I have new supporting evidence or functional assignment for gene CG12864.
Comments: Please see shaffer et al. PNAS  99:14332-7  (2002). We have indetified
the protein product of this gene as a chromosomal protein localized to
heterochromatin. We have shown by several methods that the protein interacts
with Heterochromatin protein 1 (HP1). We have also recovered EMS induced
lethal alleles of this gene, three of which are reported in the paper. Two of
the three lethal mutations act as suppressors of variegation when tested
against wm4h. We have named the gene Su(var)2-HP2 and named the protein
Heterochromatin Protein 2 (HP2). Finally we have identified a second
transcript that is produced from this locus. This transcript is an
alternative splice product that connects the end of exon 4 to the beginning of
exon 7 producing a transcript of 5081 bases (predicted from genomic sequence)
and matching well to an observed transcript on Northern blots of 5.0 Kb. We
can detect at least two protein products which match well in size with the
size predicted!
from these two transcripts (~175 kDa and ~350 kDa)