FB2026_02 , released June 18, 2026
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Citation
Goutte, C. (2002). Genetics leads the way to the accomplices of presenilins.  Dev. Cell 3(1): 6--7.
FlyBase ID
FBrf0155670
Publication Type
Review
Abstract
Presenilins mediate the gamma-secretase cleavage of Notch transmembrane receptors as well as the transmembrane beta-amyloid precursor protein (betaAPP), but they are not thought to accomplish this alone. Recent genetic screens in C. elegans, presented in this issue of Developmental Cell, identify two genes that are essential to gamma-secretase activity and may interact with presenilins.
PubMed ID
12110162
PubMed Central ID
DOI
10.1016/s1534-5807(02)00213-7
Related Publication(s)
Research paper

aph-1 and pen-2 Are Required for Notch Pathway Signaling, gamma-Secretase Cleavage of betaAPP, and Presenilin Protein Accumulation.
Francis et al., 2002, Dev. Cell 3(1): 85--97 [FBrf0151254]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference
    Genes (4)