Abstract
Reliable neurotransmitter release requires an adequate pool of synaptic vesicles. These pools are maintained by the process of endocytosis. A recent paper revealed that dynamin, a GTPase essential for endocytosis, is regulated by Abnormal wing disc (Awd), a nucleoside diphosphate kinase which converts nucleoside diphosphates to nucleoside triphosphates. This finding suggests that access to GTP directly regulates endocytosis. In addition, awd is homologous to the tumor suppressor gene nm23, further suggesting that dynamin might be involved in tumorigenesis.
