Open Close
Reference
Citation
Chyb, S., Dahanukar, A., Wickens, A., Carlson, J.R. (2003). Drosophila Gr5a encodes a taste receptor tuned to trehalose.  Proc. Natl. Acad. Sci. U.S.A. 100(Supplement 2): 14526--14530.
FlyBase ID
FBrf0168006
Publication Type
Research paper
Abstract

Recent studies have suggested that Drosophila taste receptors are encoded by a family of G protein-coupled receptor genes comprising at least 56 members. One of these genes, Gr5a, has been shown by genetic analysis to be required by the fly for behavioral and sensory responses to a sugar, trehalose. Here, we show that Gr5a is expressed in neurons of taste sensilla located on the labellum and legs. Expression is observed in most if not all labellar sensilla and suggests that many taste neurons express more than one receptor. We demonstrate by heterologous expression in a Drosophila S2 cell line that Gr5a encodes a receptor tuned to trehalose. This is the first functional expression of an invertebrate taste receptor.

PubMed ID
PubMed Central ID
PMC304113 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference
    Alleles (2)
    Genes (4)
    Sequence Features (1)
    Experimental Tools (1)
    Transgenic Constructs (2)