FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
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Citation
Tijsterman, M., Plasterk, R.H.A. (2004). Dicers at RISC; the mechanism of RNAi.  Cell 117(1-4): 1--3.
FlyBase ID
FBrf0174443
Publication Type
Note
Abstract
The pathway of RNA interference starts when Dicer cuts dsRNA into small interfering RNAs (siRNAs) that subsequently target homologous mRNAs for destruction. microRNA processing from stem loop precursors similarly requires Dicer activity. Two papers in this issue of Cell now demonstrate that Dicer is also essential for the execution phase of RNAi and explore the distinct requirements for Dicers in the siRNA and miRNA pathways.
PubMed ID
15066275
PubMed Central ID
DOI
10.1016/s0092-8674(04)00293-4
Related Publication(s)
Research paper

Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways.
Lee et al., 2004, Cell 117(1): 69--81 [FBrf0174449]

A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila.
Pham et al., 2004, Cell 117(1): 83--94 [FBrf0174450]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Genes (4)