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Citation
Sardiello, M., Tripoli, G., Romito, A., Minervini, C., Viggiano, L., Caggese, C., Pesole, G. (2005). Energy biogenesis: one key for coordinating two genomes.  Trends Genet. 21(1): 12--15.
FlyBase ID
FBrf0183426
Publication Type
Review
Abstract

In metazoan organisms, energy production is the only example of a process that is under dual genetic control: nuclear and mitochondrial. We used a genomic approach to examine how energy genes of both the nuclear and mitochondrial genomes are coordinated, and discovered a novel genetic regulatory circuit in Drosophila melanogaster that is surprisingly simple and parsimonious. This circuit is based on a single DNA regulatory element and can explain both intra- and inter-genomic coordinated expression of genes involved in energy production, including the full complement of mitochondrial and nuclear oxidative phosphorylation genes, and the genes involved in the Krebs cycle.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Trends Genet.
    Title
    Trends in Genetics
    Publication Year
    1985-
    ISBN/ISSN
    0168-9525
    Data From Reference